Advancing Paediatric Clinical Research Reporting with TEDDY’s Expertise
TEDDY is proud to announce its contribution to a significant article titled “Transparent Reporting of Pediatric Clinical Trial Interventions: TIDieR-Children and Adolescents”, recently published in the journal Pediatrics. You can read the article at the following LINK.
The article introduces the Template for the Intervention Description and Replication (TIDieR) framework aimed at improving the transparency and quality of reporting in paediatric randomized controlled trials (RCTs). Furthermore, it emphasizes the critical need for clear, detailed reporting of trial interventions in paediatric research, which is essential for ensuring the replicability and effectiveness of evidence-based treatments.
The content has been developed by an international team of experts including Giorgio Reggiardo, Chair of the TEDDY Working Group (WG) on Paediatric Research Methodologies and a member of TEDDY Board of Directors, and Karel Allegaert, TEDDY Member and paediatrician-neonatologist and clinical pharmacologist, appointed as Professor at Katholieke Universiteit (KU) Leuven and as senior clinical consultant at Erasmus MC Rotterdam.
Through a rigorous process, the team reached consensus on 13 paediatric-specific considerations, which are compiled in the TIDieR-Child & Adolescent Health (TIDieR-C) checklist. This checklist provides a minimum set of guidelines for comprehensive reporting and evaluation of paediatric trial interventions. Additionally, TIDieR-C is designed to be used alongside the established CONSORT and SPIRIT Statements and their paediatric extensions, CONSORT-Children & Adolescents and SPIRIT-Children & Adolescents to promote clear, transparent, and replicable reporting of interventions in clinical studies involving children and adolescents. The TIDieR-C guidance addresses the unique challenges of paediatric trials, such as ensuring interventions are age-appropriate, enhancing the acceptability of treatments, and determining paediatric-specific dosages.
The adoption of these guidelines could significantly improve the quality of paediatric clinical research, ensuring that interventions are both scientifically robust and effectively implemented for children and adolescents.
TEDDY’s involvement in this publication highlights its ongoing commitment to advancing high-quality paediatric research and defining international standards for the reporting and implementation of interventions in paediatric clinical trials.
You can find more information on TEDDY Publications at the following LINK.