PUBLICATIONS
Innovations in Paediatric Research:
TEDDY Network’s Contributions
The TEDDY Network drives innovation in paediatric research by enhancing drug development, ethics, and clinical trials for children. Through collaborative projects, it advances regulatory science and patient-centred approaches, ensuring safer and more effective treatments for young patients worldwide.
2025
Katherine Goren, Veronica Ka Wai Lai, Ami Baba, Maureen Smith, Karel Allegaert, Nancy J. Butcher, Ricardo Fernandes, Peter J. Gill, Lisa Hartling, Edmund Juszczak, Patricia E. Longmuir, Colin Macarthur, Kayur Mehta, David Metz, Kim An Nguyen, Michal Odermarsky, Ramesh Poluru, Diane Purper-Ouakil, Giorgio Reggiardo, Catherine Stratton, Peter Szatmari, Amit Trivedi, Julia Upton, Tammy Hoffmann, Martin Offringa; Transparent Reporting of Pediatric Clinical Trial Interventions: TIDieR-Children and Adolescents. Pediatrics 2025; e2025072867. 10.1542/peds.2025-072867
https://doi.org/10.1542/peds.2025-072867
Reggiardo G, Natale A, Santoro N, Giannuzzi V, Pansieri C, Felisi M, Bonifazi D and Ceci A (2025) Scientific and regulatory progress in advancing paediatric oncology drug development in the EU and in the US.
Front. Med. 12:1642279.
2024
Giannuzzi V, Bertolani A, Torretta S, Reggiardo G, Toich E, Bonifazi D and Ceci A (2024); Innovative research methodologies in the EU regulatory framework: an analysis of EMA qualification procedures from a pediatric perspective. Front. Med. 11:1369547. doi: 10.3389/fmed.2024.1369547
Landi A, Mimouni Y, Giannuzzi V, Schaefer F, Altavilla A, Gibson S and Julkowska D (2024); The creation of an adaptable informed consent form for research purposes to overcome national and institutional bottlenecks in ethics review: experience from rare disease registries. Front. Med. 11:1384026. doi:10.3389/fmed.2024.1384026
2023
de Wildt SN, Foeldvari I, Siapkara A, Lepola P, Kriström B, Ruggieri L, Eichler I, Egger GF. Off-label is not always off-evidence: authorising paediatric indications for old medicines. Lancet Child Adolesc Health. 2023 Apr 25:S2352-4642(23)00083-4. doi: 10.1016/S2352-4642(23)00083-4
Giannuzzi V, Ruggieri L, Conte R, Manfredi C, Felisi M, Kubiak C, Matei M, Malik S, Demotes J, Ceci A, Bonifazi D. PedCRIN tool for the biosamples management in paediatric clinical trials. Clin Transl Sci. 2023 Feb 9. doi: 10.1111/cts.13489 (cited in Acknowledgements)
2022
Giannuzzi V, Stoyanova-Beninska V and Hivert V (2022) Editorial: The use of real world data for regulatory purposes in the rare diseases setting. Front. Pharmacol. 13:1089033. doi: 10.3389/fphar.2022.1089033
Sultana J, Crisafulli S, Almas M, Antonazzo I, Baan E, Bartolini C, Bertuccio MP, Bonifazi F, Capuano A, Didio A and all; Overview of the EU PAS register post-authorization studies performed in Europe from September 2010 to December 2018 , Pharmacoepidemiol Drug Saf 2022 Jan 29. doi: 10.1002/pds.5413. Online ahead of print
2021
Lepola P, Kindred M, Giannuzzi V, Glosli H, Dehlinger-Kremer M, Dalrymple H, Neubauer D, Boylan GB, Conway J, Dewhurst J, Hoffman D. Informed consent and assent guide for paediatric clinical trials in Europe. Arch Dis Child 2021;0:1–9. doi:10.1136/archdischild-2021-322798
Giannuzzi V, Felisi M, Bonifazi D, Devlieger H, Papanikolaou G, Ragab L, Fattoum S, Tempesta B, Reggiardo G, Ceci A. Ethical and procedural issues for applying researcher-driven multi-national paediatric clinical trials in and outside the European Union: the challenging experience of the DEEP project. BMC Med Ethics. 2021 Apr 29;22(1):49. doi: 10.1186/s12910-021-00618-2. PMID: 33926431. (cited in Acknowledgements)
Ruggieri L, Ceci A, Bartoloni F, Elie V, Felisi M, Jacqz-Aigrain E, Lupo M, Malik S, Manfredi C, Reggiardo G, Demotes J, Bonifazi D. Paediatric clinical research in Europe: an insight on experts’ needs and perspectives. Contemp Clin Trials Commun. 2021 Feb 10;21:100735. doi: 10.1016/j.conctc.2021.100735. PMID: 33665471; PMCID: PMC7905444.
Toma M, Felisi MG, Bonifazi D, Bonifazi F, Giannuzzi V, Reggiardo G, de Wildt S, Ceci A and TEDDY European Network of Excellence for Paediatric Research. Paediatric Medicines in Europe: The Paediatric Regulation—Is It Time for Reform?. Front. Med. 2021 Feb; 8:593281. doi: 10.3389/fmed.2021.593281
2020
Aurich B, Vermeulen E, Elie V, Driessens MHE, Kubiak C, Bonifazi D, Jacqz-Aigrain E.
Informed consent for neonatal trials: practical points to consider and a checklist.
BMJ Paediatrics Open. 29 December 2020; doi: 10.1136/bmjpo-2020-000847
Altavilla A, Giannuzzi A, Lupo M, Bonifazi D, Ceci A. Ethical, Legal and Regulatory Issues of Paediatric Translational Research. Call for an Adequate Model of Governance. European Journal of Health Law. May 2020. 1–19. Available at: https://brill.com/view/journals/ejhl/27/3/article-p213_3.xml
Gini R, Sturkenboom MC, Sultana J, Cave A, Landi A, Pacurariu A, Roberto G, Schink T, Candore G, Slattery J, Trifirò G; Working Group 3 of ENCePP. Different strategies to execute multi‐database studies for medicines surveillance in real world setting: a reflection on the European model. Clin Pharmacol Ther. 2020 Apr 3. doi: 10.1002/cpt.1833
2019
Ruggieri L, Bonifazi D, Landi A, Bonifazi F, Bartoloni F, Costello M, Grazia Felisi M, Gasthuys E, Godo A, Martinon Torres F, Nadal D, Nuytinik L, Rocchi F, Turner M, Ceci A. Survey by TEDDY – European Network of Excellence for Paediatric Clinical Research demonstrates potential for Europe-wide trials. Acta Paediatr. 2019 Sep 18. doi: 10.1111/apa.15020. [Epub ahead of print] PubMed
PMID: 31532836. Available at: https://onlinelibrary.wiley.com/doi/abs/10.1111/apa.15020
Bueno-Campaña M, Sainz T, Alba M, Del Rosal T, Mendez-Echevarría A, Echevarria R, Tagarro A, Ruperez-Lucas M, Herrreros ML, Latorre L, Calvo C. Lung ultrasound for prediction of respiratory support in infants with acute bronchiolitis: A cohort study. Pediatr Pulmonol. 2019 Jun;54(6):873-880. doi: 10.1002/ppul.24287. Epub 2019 Mar 5. PubMed PMID: 30838805. Available at: https://onlinelibrary.wiley.com/doi/abs/10.1002/ppul.24287
Martín Del Valle F, Menasalvas Ruiz A, Cilla A, González AV, de Ceano Vivas M, Cabrerizo Sanz M, Calvo C. Neurodevelopment medium-term outcome after parechovirus infection. Early Hum Dev. 2019 May; 132:1-5. Doi:10.1016/j.earlhumdev.2019.03.005. Epub 2019 Mar 22. PubMed PMID: 30908988. Available at: https://www.sciencedirect.com/science/article/abs/pii/S0378378218306522?via%3Dihub
Calvo C, Millan C, Romero MP, Méndez-Echevarría A. Could human bocavirus be a causative agent of parotitis in children? Enferm Infecc Microbiol Clin. 2019 Mar;37(3):207-208. doi: 10.1016/j.eimc.2018.04.001. Epub 2018 May 8. English, Spanish. PubMed PMID: 29751940. Available at: https://www.sciencedirect.com/science/article/pii/S0213005X18301691?via%3Dihub
Intini A., Bonifazi D, Migliaccio G. Challenges and New Frontiers in the Paediatric Drug Discovery and Development (Book chapter). Drug Discovery and Development – New Advances. 2019 Apr 8. Publisher: IntechOpen. DOI: http://dx.doi.org/10.5772/intechopen.85635. Available at: https://www.intechopen.com/online-first/challenges-and-new-frontiers-in-the-paediatric-drug-discovery-and-development
Benavides-Nieto M, Méndez-Echevarría A, Del Rosal T, García-García ML, Casas I, Pozo F, de la Serna O, Lopez-Granados E, Rodriguez-Pena R, Calvo C. The role of respiratory viruses in children with humoral immunodeficiency on immunoglobulin replacement therapy. Pediatr Pulmonol. 2019 Feb;54(2):194-199. doi: 10.1002/ppul.24214. Epub 2018 Dec 21. PubMed PMID: 30575324. Available at: https://onlinelibrary.wiley.com/doi/abs/10.1002/ppul.24214
2018
Lupo M, Intini A, Filannino D. Informed Participation and Patient Empowerment: A Patient-Centered Approach to Improve Pediatric Clinical Research. The Management of Clinical Trials, 978-1-78923-239-4; Publisher: Intech, June, 6th 2018. Available at: https://www.intechopen.com/books/the-management-of-clinical-trials/informed-participation-and-patient-empowerment-a-patient-centered-approach-to-improve-pediatric-clin
Chiaruttini G, Felisi M and Bonifazi D. Challenges in Paediatric Clinical Trials: How to Make It Feasible. The Management of Clinical Trials, 978-1-78923-239-4; Publisher: Intech, June, 6th 2018. Available at: https://www.intechopen.com/books/the-management-of-clinical-trials/challenges-in-paediatric-clinical-trials-how-to-make-it-feasible
Alcobendas R, Remesal A, Murias S, Nuñez E, Calvo C. Outpatients with acute osteoarticular infections had favourable outcomes when they received just oral antibiotics without intravenous antibiotics. Acta Paediatr. 2018 Apr 29. doi: 10.1111/apa.14373. [Epub ahead of print] PMID: 29705992. Available at: https://onlinelibrary.wiley.com/doi/abs/10.1111/apa.14373
Martín Del Valle F, Calvo C, Martinez-Rienda I, Cilla A, Romero MP, Menasalvas AI, Reis-Iglesias L, Roda D, Pena MJ, Rabella N, Portugués de la Red MDM, Megías G, Moreno-Docón A, Otero A, Cabrerizo M; Grupo de Estudio de las infecciones por enterovirus y parechovirus en niños. Epidemiological and clinical characteristics of infants admitted to hospital due to human parechovirus infections: A prospective study in Spain. An Pediatr (Barc). 2018 Feb;88(2):82-88. doi: 10.1016/j.anpedi.2017.02.009. Epub 2017 Mar 30. Spanish. PMID: 28365283. Available at: https://www.ncbi.nlm.nih.gov/pubmed/28365283
Mellado Peña MJ, Santiago García B, Baquero-Artigao F, Moreno Pérez D, Piñeiro Pérez R, Méndez Echevarría A, Ramos Amador JT, Gómez-Pastrana Durán D, Noguera Julian A; Grupo de Trabajo de Tuberculosis e Infección por otras Micobacterias de la Sociedad Española de Infectología Pediátrica. [Tuberculosis treatment for children: An update]. An Pediatr (Barc). 2018 Jan;88(1): 52.e1-52.e12. doi: 10.1016/j.anpedi.2017.05.013. Epub 2017 Jul 18. Spanish. PubMed PMID: 28729186. Available at: https://www.analesdepediatria.org/en-tuberculosis-treatment-for-children-an-articulo-S2341287917302041
2017
Garcia-Garcia ML, Calvo C, Ruiz S, Pozo F, Del Pozo V, Remedios L, Exposito N, Tellez A, Casas I. Role of viral coinfections in asthma development. PLoS One. 2017 Dec 5;12(12):e0189083. doi: 10.1371/journal.pone.0189083. eCollection 2017. PMID: 29206851. Available at: https://www.ncbi.nlm.nih.gov/pubmed/29206851
Veal GJ, Malik S, Lupo M, MacFarlane S, Lepola P, Costello M, Ceci A, Boué C, Lecour C, Otto A, Rastegari M, Berry P. Investigating the roles and training of paediatric research nurses working across Europe: a questionnaire-based survey.BMJ Paediatr Open. 2017 Sep 5;1(1):e000170. doi: 10.1136/bmjpo-2017-000170.eCollection2017. http://bmjpaedsopen.bmj.com/content/1/1/e000170
García-García ML, Calvo C, Moreira A, Cañas JA, Pozo F, Sastre B, Quevedo S, Casas I, del Pozo V. Thymic Stromal Lymphopoietin, IL-33 and periostin in hospitalized infants with viral bronchiolitis. Medicine (Baltimore). 2017 May;96(18):e6787. Available at: https://www.ncbi.nlm.nih.gov/pubmed/28471975
Giannuzzi V, Devlieger H, Margari L, Odlind VL, Ragab L, Bellettato CM, D’Avanzo F, Lampe C, Cassis L, Cortès-Saladelafont E, Cazorla ÁG, Barić I, Cvitanović-Šojat L, Fumić K, Dali CI, Bartoloni F, Bonifazi F, Scarpa M, Ceci A. The ethical framework for performing research with rare inherited neurometabolic disease patients. European Journal of Pediatrics. 2017 Mar; 176(3):395-405. Epub 2017 Jan 16. https://link.springer.com/article/10.1007%2Fs00431-017-2852-9
Garcìa ML, Calvo C, Rey C, Dìaz B, Molinero M, Pozo F, Casas I (2017). Human metapnuemovirus infections in hospitalized children and comparison with other respiratory viruses. 2005-2014 prospective study. PLoS ONE 12(3): e0173504
2016
Paola D’andria, Viviana Giannuzzi, Fedele Bonifazi, Adriana Ceci, Nunzio Denora, Cosimo D. Altomare. Formulating medicines for children: challenges and issues. DOI: http://dx.medra.org/10.17374/CI.2016.98.3.4
2015
Ceci A, Giannuzzi V, Bonifazi D, Felisi M, Bonifazi F and Ruggieri L Clinical Trials in Paediatrics — Regulatory and Methodological Aspects. Drug Discovery and Development – From Molecules to Medicine, Prof. Omboon Vallisuta (Ed.), ISBN: 978-953-51-2128-2, InTech, DOI: 10.5772/60611. Available at: http://www.intechopen.com/books/drug-discovery-and- development-from-molecules-to-medicine/clinical-trials-in-paediatrics- regulatory-and-methodological-aspects
Giannuzzi V, Altavilla A, Ruggieri L, Ceci A. Clinical Trial Application in Europe: What Will Change with the New Regulation? Sci Eng Ethics. 2015 Jun 3. [Epub ahead of print] https://www.ncbi.nlm.nih.gov/pubmed/26037896
Ruggieri L, Giannuzzi V, Baiardi P, Bonifazi F, Davies EH, Giaquinto C, Bonifazi D, Felisi M, Chiron C, Pressler R, Rabe H, Whitaker MJ, Neubert A, Jacqz-Aigrain E, Eichler I, Turner MA, Ceci A; GRiP Consortium. Successful private-public funding of paediatric medicines research: lessons from the EU programme to fund research into off-patent medicines. Eur J Pediatr. 2015 Apr;174(4):481-91. doi: 10.1007/s00431-014-2398-z. Epub 2014 Sep 23
2014
Piñeiro Péreza R, Ruiz Antoránb MB, Avendaño Solá C, Román Riechmann E, Cabrera García L, Cilleruelo Ortega ML, Mellado Peña MJ. Conocimiento sobre el uso de fármacos off-label en Pediatría. Resultados de una encuesta pediátrica nacional 2012-2013 (estudio OL-PED). An Pediatr (Barc). 2014; 81(1):16-21. Avalaible at: http://www.analesdepediatria.org/es/conocimiento-sobre-el-uso- farmacos/articulo/S1695403313004086/
Piñeiro Pérez R, Martínez Fernández-Llamazares C, Calvo Rey C, Piñeiro Pérez AP, Criado Vega EA, Bravo Acuña J, Cabrera García L, Mellado Peña MJ Asociación Española de Pediatría, Pediamécum: un año de experiencia. An Pediatr (Barc). 2014;81(4):257.e1-257.e6. Available at: http://analesdepediatria.org/es/pediamecum-un-ano- experiencia/articulo/S1695403314001015/
2012
Altavilla A, Manfredi C, Baiardi P, Dehlinger-Kremer M, Galletti P, Pozuelo AA, Chaplin J, Ceci A. Impact of the new European paediatric regulatory framework on ethics committees: overview and perspectives.
Acta Paediatr. 2012 Jan;101(1):e27-e32.
DOI: 10.1111/j.1651-2227.2011.02401.x
Epub 2011 Jul 23.
2011
Utilidad, implementación e impacto de la Red TEDDY en Europa.
Mellado Peña MJ, Piñeiro Pérez R, Medina Claros AF, Ceci A. Farm Hosp. 2011 Jul 21. [Epub ahead of print]
Russo R, Capasso M, Paolucci P, Iolascon A, TEDDY European Network of Excellence. Pediatric pharmacogenetic and pharmacogenomic studies: the current state and future perspectives. Eur J Clin Pharmacol. 2011 May;67 Suppl 1:17-27. doi: 10.1007/s00228-010-0931-1. Epub 2010 Nov 11. https://pubmed.ncbi.nlm.nih.gov/21069522/
Scarpa M, Ceci A, Tomanin R, Mincarone P, Begley D. Personalised medicine in paediatrics: Individualising treatment in children with rare neurological diseases. EPMA Journal (2011) 2:231–239. doi: 10.1007/s13167-011 00812. Epub 2011 May 1.https://pubmed.ncbi.nlm.nih.gov/23199151/
Effects of safety warnings on prescription rates of cough and cold medicines in children below 2 years of age.
Sen EF, Verhamme KM, Felisi M, ‘t Jong GW, Giaquinto C, Picelli G, Ceci A, Sturkenboom MC; TEDDY European Network of Excellence.
Br J Clin Pharmacol. 2011 Jun;71(6):943-50. DOI: 10.1111/j.1365-2125.2010.03860.x
Mortality rates and causes of death in children with epilepsy prescribed antiepileptic drugs: a retrospective cohort study using the UK General Practice Research Database.
Ackers R, Besag FM, Hughes E, Squier W, Murray ML, Wong IC.
Drug Saf. 2011 May 1;34(5):403-13. doi: 10.2165/11588480-000000000-00000.
Assessment of Pediatric asthma drug use in three European countries; a TEDDY study.
Sen EF, Verhamme KM, Neubert A, Hsia Y, Murray M, Felisi M, Giaquinto C, ‘t Jong GW, Picelli G, Baraldi E, Nicolosi A, Ceci A, Wong IC, Sturkenboom MC; on behalf of the TEDDY European Network of Excellence.
Eur J Pediatr. 2011 Jan;170(1):81-92. DOI: 10.1007/s00431-010-1275-7
Brasseur D. Paediatric research and the regulation “better medicines for the children in Europe”. Eur J Clin Pharmacol. 2011 May;67 Suppl 1:1-3. Doi: 10.1007/s00228-011-1034-3. Epub 2011 Mar 29. PMID: 21445636. DOI: 10.1007/s00228-011-1034-3
Changes in Research and Development of Medicinal Products since the Paediatric Regulation.
Catapano M, Manfredi C, Wong I, Orlu-Gul M, Meneguz M, Baiardi P, Della Pasqua O, Iolascon A, Scarpa M, Neubert A, Ceci A.
Chris Rundfeldt (ed): Drug Development – A Case Study Based Insight into Modern Strategies. InTech, December 2011, pp 585-638. DOI: 10.5772/28797
Innovative study design for paediatric clinical trials.
Baiardi P, Giaquinto C, Girotto S, Manfredi C, Ceci A; on behalf of the TEDDY Network of Excellence. Eur J Clin Pharmacol. 2011 May;67 Suppl 1:109-15.
DOI: 10.1007/s00228-011-0990-y
Do pharmacokinetic polymorphisms explain treatment failure in high-risk patients with neuroblastoma?
Bellanti F, Kågedal B, Della Pasqua O.
Eur J Clin Pharmacol. 2011 May;67 Suppl 1:87-107
DOI: 10.1007/s00228-010-0966-3
Modelling and simulation as research tools in paediatric drug development.
Bellanti F, Della Pasqua O.
Eur J Clin Pharmacol. 2011 May;67 Suppl 1:75-86.
DOI: 10.1007/s00228-010-0974-3
Study designs in paediatric pharmacoepidemiology.
Verhamme K, Sturkenboom M.
Eur J Clin Pharmacol. 2011 May;67 Suppl 1:67-74
DOI: 10.1007/s00228-010-0930-2
Endpoints in pediatric pain studies.
Van Dijk M, Ceelie I, Tibboel D.
Eur J Clin Pharmacol. 2011 May;67 Suppl 1:61-6.
DOI: 10.1007/s00228-010-0947-6
Endpoints in respiratory diseases.
De Benedictis FM, Guidi R, Carraro S, Baraldi E; on behalf of the TEDDY European Network of Excellence.
Eur J Clin Pharmacol. 2011 May;67 Suppl 1:49-59.
Quality of life in clinical trials for children.
Trama A, Dieci M.
Eur J Clin Pharmacol. 2011 May;67 Suppl 1:41-7. DOI: 10.1007/s00228-010-0924-0
Criteria to define response to therapy in paediatric rheumatic diseases.
Ruperto N, Pistorio A, Ravelli A, Hasija R, Guseinova D, Filocamo G, Demirkaya E, Malattia C, Martini A; for the Paediatric Rheumatology International Trials Organisation (PRINTO).
Eur J Clin Pharmacol. 2011 May;67 Suppl 1:125-31.
DOI: 10.1007/s00228-010-0937-8
Ethical key issues and fundamental rights in paediatric research.
Altavilla A.
Eur J Clin Pharmacol. 2011 May;67 Suppl 1:117-23.
DOI: 10.1007/s00228-010-0929-8
Endpoints in paediatric oncology.
Paolucci P, Cioni V, Bigi E, Lucaccioni L, Cano C.
Eur J Clin Pharmacol. 2011 May;67 Suppl 1:33-40.
Clinical research in newborn infants: difficulties and specificity.
Ligi I, Boubred F, Grandvuillemin I, Simeoni U.
Eur J Clin Pharmacol. 2011 May;67 Suppl 1:29-32.
DOI: 10.1007/s00228-010-0921-3
The role of population PK-PD modelling in paediatric clinical research.
De Cock RF, Piana C, Krekels EH, Danhof M, Allegaert K, Knibbe CA.
Eur J Clin Pharmacol. 2011 May;67 Suppl 1:5-16.
DOI: 10.1007/s00228-009-0782-9
Cardiovascular risk markers are increased in HIV-infected children with lipodystrophy syndrome.
Guzmán-Fulgencio M, Micheloud D, Lorente R, Bellón JM, Gomez MI, Gurbindo MD, León JA, Muñoz-Fernández MÁ, Resino S.
J Infect. 2011 Mar;62(3):240-3.
DOI: 10.1016/j.jinf.2011.01.008
Adipokine profiles and lipodystrophy in HIV-infected children during the first 4 years on highly active antiretroviral therapy.
Resino S, Micheloud D, Lorente R, Bellon JM, Navarro ML, Munoz-Fernandez MA.
HIV Med. 2011 Jan;12(1):54-60.
2010
Análisis ecológico y perfil materno de la transmisión vertical del virus de la inmudeficiencia humana en la Comunidad de Madrid desde 1980 hasta 2008.
García-Alonso D, Palladino C, Bellón JM, Resino S, Guillén S, Gurbindo D, de José MI, Ramos JT, Mellado MJ, Beceiro J, Martínez Pérez J, Calvo C, Izusquiza D, Muñoz-Fernández MA.
Act Petriar Esp. 2010;68(6):292-300.
Análisis socioeconómico y demográfico de la prevalencia en niños infectados por el virus de la inmunodeficiencia humana por transmisión vertical en la Comunidad de Madrid.
García-Alonso D, Palladino C, Bellón JM, Resino S, Guillén S, Gurbindo D, de José MI, Ramos JT, Mellado MJ, Beceiro J, Martínez Perez J, Calvo C, Izuzquiza D, Muñoz-Fernández MA.
Act Pediatr Esp. 2010; 68(5):235-240.
The prescribing of analgesics and non-steroidal anti-inflammatory drugs in paediatric primary care in the UK, Italy and the Netherlands.
Neubert A, Verhamme K, Murray ML, Picelli G, Hsia Y, Sen FE, Giaquinto C, Ceci A, Sturkenboom M, Wong IC; On behalf of the TEDDY Network of Excellence.
Pharmacol Res. 2010 Sep;62(3):243-8. DOI: 10.1016/j.phrs.2010.04.006
In-label and off-label use of respiratory drugs in the Italian paediatric population.
Baiardi P, Ceci A, Felisi M, Cantarutti L, Girotto S, Sturkenboom M, Baraldi E.
Acta Paediatr. 2010 Apr;99(4):544-9. DOI: 10.1111/j.1651-2227.2009.01668.x
Comparison of antiepileptic drug prescribing in children in three European countries.
Hsia Y, Neubert A, Sturkenboom MC, Murray ML, Verhamme KM, Sen F, Giaquinto C, Ceci A, Wong IC; on behalf of the TEDDY Network of Excellence.
Epilepsia. 2010 May;51(5):789-96. DOI: 10.1111/j.1528-1167.2009.02331.x
Impairment of stimulation ability of very-preterm neonatal monocytes in response to lipopolysaccharide.
Pérez A, Bellón JM, Gurbindo MD, Muñoz-Fernández MA.
Hum Immunol 2010; 71: 151-7.
DOI: 10.1016/j.humimm.2009.11.011
Can serum hyaluronic acid replace simple non-invasive indexes to predict liver fibrosis in HIV/Hepatitis C coinfected patients?
Resino S, Bellon JM, Asensio C, Micheloud D, Miralles P, Vargas A, Catalan P, Lopez JC, Alvarez E, Cosin J, Lorente R, Munoz-Fernandez MA, Berenguer J. BMC Infect Dis. 2010 Aug 19;10:244.
Association between lipodystrophy and leptin in human immunodeficiency virus-1-infected children receiving lopinavir/ritonavir-based therapy.
Resino S, Palladino C, Lorente R, Micheloud D, Maria Bellón J, Larru B, Gutiérrez MD, de José MI, Polo R, Muñoz-Fernández MA; on Behalf of the Spanish Group of Pediatric HIV Infection. .
Pediatr Infect Dis J. 2010 Aug;29(8):774-7.
2009
The Task-force in Europe for Drug Development for the Young (TEDDY) Network of Excellence.
Ceci A, Giaquinto C, Aboulker JP, Baiardi P, Bonifazi F, Della Pasqua O, Nicolosi A, Taruscio D, Sturkenboom M, Wong I.
Paediatr Drugs. 2009;11(1):18-21. 10.2165/0148581-200911010-00008
Mortality associated with attention-deficit hyperactivity disorder (ADHD) drug treatment: a retrospective cohort study of children, adolescents and young adults using the general practice research database.
McCarthy S, Cranswick N, Potts L, Taylor E, Wong IC.
Drug Saf. 2009;32(11):1089-96. DOI: 10.2165/11317630-000000000-00000
Minimising medication errors in children
Wong ICK, Wong LYL, Cranswick NE.
Arch. Dis. Child. 2009;94;161-164. DOI: 10.1136/adc.2007.116442
Attention-deficit hyperactivity disorder: treatment discontinuation in adolescents and young adults.
McCarthy S, Asherson P, Coghill D, Hollis C, Murray M, Potts L, Sayal K, de Soysa R, Taylor E, Williams T, Wong IC.
Br J Psychiatry. 2009 Mar;194(3):273-7. DOI: 10.1192/bjp.bp.107.045245
Changing trends in antiepileptic drug prescribing in girls of child-bearing potential.
Ackers R, Besag FM, Wade A, Murray ML, Wong IC.
Arch Dis Child. 2009 Jun;94(6):443-7. DOI: 10.1136/adc.2008.144386
Effect of antibiotics for otitis media on mastoiditis in children: a retrospective cohort study using the United kingdom general practice research database.
Thompson PL, Gilbert RE, Long PF, Saxena S, Sharland M, Wong IC.
Pediatrics. 2009 Feb;123(2):424-30. DOI: 10.1542/peds.2007-3349
Different profiles of apoptosis and activation in children with progressive or static HIV-related encephalophaty.
Blanco A, Nardacci R, Del Nonno F, Callea F, Francalanci P, Piacentini M and Muñoz-Fernández MA.
J Pediat Infect Dis 2009;4(4):367-73.
2008
Drug use in children: cohort study in three European countries.
Sturkenboom MC, Verhamme KM, Nicolosi A, Murray ML, Neubert A, Caudri D, Picelli G, Sen EF, Giaquinto C, Cantarutti L, Baiardi P, Felisi MG, Ceci A, Wong IC; TEDDY European Network of Excellence. BMJ. 2008 Nov 24;337:a2245. DOI: 10.1136/bmj.a2245
Databases for pediatric medicine research in Europe–assessment and critical appraisal.
Neubert A, Sturkenboom MC, Murray ML, Verhamme KM, Nicolosi A, Giaquinto C, Ceci A, Wong IC; TEDDY Network of Excellence.
Pharmacoepidemiol Drug Saf. 2008 Dec;17(12):1155-67. DOI: 10.1002/pds.1661
Epidemiologic features of antipsychotic prescribing to children and adolescents in primary care in the United Kingdom.
Rani F, Murray ML, Byrne PJ, Wong IC.
Pediatrics. 2008 May;121(5):1002-9. DOI: 10.1542/peds.2007-2008
Has UK guidance affected general practitioner antibiotic prescribing for otitis media in children?
Thompson PL, Gilbert RE, Long PF, Saxena S, Sharland M, Wong IC.
J Public Health (Oxf). 2008 Dec;30(4):479-86. DOI: 10.1093/pubmed/fdn072
Spatial pattern of HIV-1 mother-to-child-transmission in Madrid (Spain) from 1980 till now: demographic and socioeconomic factors.
Palladino C, Bellón JM, Pérez-Hoyos S, Resino R, Guillén S, García D, Gurbindo MD, Ramos JT, de José MI, Mellado MJ, Muñoz-Fernández MA.
AIDS. 2008; 22: 2199-205. DOI: 10.1097/QAD.0b013e328310fa96
Bases para el uso clínico de fármacos para niños. Situación actual de uso de fármacos pediátricos en España
Medina-Claros AF, Mellado-Peña MJ, Baquero-Artigao F.
An Pediatr Contin. 2008; 6(3):187-190.
Altavilla A, Giaquinto C, Ceci A.
J Int Bioethique. 2008 Sep;19(3):17-48, 121-2.
Defining off-label and unlicensed use of medicines for children: Results of a Delphi survey.
Neubert A, Wong IC, Bonifazi A, Catapano M, Felisi M, Baiardi P, Giaquinto C, Knibbe CA, Sturkenboom MC, Ghaleb MA, Ceci A.
Pharmacol Res. 2008 Nov-Dec;58(5-6):316-22.
DOI: 10.1016/j.phrs.2008.09.007
Clinical research with children: the European legal framework and its implementation in French and Italian law.
Altavilla A.
Eur J Health Law. 2008 Jul;15(2):109-25.
Challenges in prescribing drugs for children with cancer
Paolucci P, Jones KP, del Carmen Cano Garcinuno M, Catapano M, Iolascon A, Ceci A.
Lancet Oncol. 2008 Feb;9(2):176-83.
2007
The Teddy Network: epidemiological trends in paediatric drug use in Europe
Sturkenboom M, Fatma E, Verhamme K, Herings R, Neubert A, Felisi M, Ceci A.
EJHP Practice 2007; 13(6):22-24.
Pharmacogenetics and paediatric drug development: issues and consequences to labelling and dosing recommendations.
Krekels EH, van den Anker JN, Baiardi P, Cella M, Cheng KY, Gibb DM, Green H, Iolascon A, Jacqz-Aigrain EM, Knibbe CA, Santen GW, van Schaik RH, Tibboel D, Della Pasqua OE.
Expert Opin Pharmacother. 2007 Aug;8(12):1787-99.
DOI: 10.1517/14656566.8.12.1787
Prioritizing children’s medicines for research: a pharmacoepidemiological study of antiepileptic drugs
Ackers R, Murray ML, Besag FMC, Wong ICK.
Br J Clin Pharmacol. 2007 Jun;63(6):689-97.
DOI: 10.1111/j.1365-2125.2006.02842.x
Study and Protocol Design for Paediatric Patients of Different Ages
Della Pasqua O, Zimmerhackl L, Rose K.
Rose K, van den Anker JN (eds): Guide to Paediatric Clinical Research. Basel, Karger, 2007, pp 87- 107.
2006
Medicines for children licensed by the European Medicines Agency (EMEA): the balance after 10 years
Ceci A, Felisi M, Baiardi P, Bonifazi F, Catapano M, Giaquinto C, Nicolosi A, Sturkenboom M, Neubert A, Wong I.
Eur J Clin Pharmacol 2006. Nov;62(11):947-52.